Superdrol (Methasterone) — Designer Steroid — Anabolic Steroids
Designer anabolic steroid with extreme potency and hepatotoxicity. No pharmaceutical approval. Previously sold as a supplement before being banned.
Overview
Methasterone (Superdrol, methyldrostanolone) is a 17-alpha-alkylated derivative of drostanolone (Masteron) that was marketed as a 'prohormone' dietary supplement in the United States from 2005 to 2012 under the brand name Superdrol, despite being a potent anabolic steroid. It was added to the Controlled Substances Act in 2012 under the Designer Anabolic Steroid Control Act. Methasterone has an estimated anabolic:androgenic ratio of 400:20, making it extremely anabolic with low androgenic activity. It does not aromatize to estrogen and produces dry, lean gains. However, methasterone is exceptionally hepatotoxic — among the most liver-toxic oral steroids ever created. Numerous case reports document severe cholestatic liver injury, including cases requiring liver transplantation, following use at typical bodybuilding doses of 10-30 mg daily for just 2-4 weeks. The hepatotoxicity is believed to stem from the combination of 17-alpha-alkylation and the 2-alpha-methyl group, which creates a metabolite profile particularly damaging to hepatocytes. Methasterone has no legitimate medical use and has never been subject to clinical trials. All safety data derive from case reports of adverse events in recreational users.
Indications
- No legitimate medical indications
- No clinical trials ever conducted
- Unapproved: Lean mass gains (bodybuilding use — extreme risk)
Mechanism of Action
Methasterone activates the androgen receptor with very high anabolic potency (ratio 400:20) relative to its androgenic effects
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Methasterone (Superdrol) | 10-20 mg | Once daily | Bodybuilding dose — extreme hepatotoxicity at ANY dose |
Safety & Contraindications
- EXTREME hepatotoxicity — liver transplantation cases documented
- Cholestatic jaundice, liver failure at standard bodybuilding doses
- No clinical safety data — all data from adverse event case reports
- Severe HDL suppression and adverse lipid effects
- HPG axis suppression
- Lethargy and fatigue common (likely hepatic stress manifestation)
- Schedule III controlled substance (added 2012)
- One of the most dangerous oral steroids in existence