HPG-Axis Modulation (Grade B for IVF) — Stacking Protocols
IVF oocyte maturation trigger, LH/testosterone support and reproductive hormone optimization
Overview
Kisspeptin-54/10 for IVF oocyte maturation (GRADE B: multiple RCTs, n=175+ women, 95-96% maturation, 45% live birth rate). Superior OHSS prevention vs hCG (33.6× lower risk). NOT FDA-approved; investigational in specialized fertility centers.
Indications
- LH/testosterone support and reproductive hormone optimization
- Synergistic peptide combination therapy
- Multi-pathway optimization
Mechanism of Action
Kisspeptin binds KISS1R on GnRH neurons in hypothalamus
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Kisspeptin | See dosing notes | As per protocol | Follow detailed dosing schedule below |
Evidence Grade
GRADE B
Safety & Contraindications
- Requires physician supervision for peptide stacking
- Monitor for additive or synergistic side effects
- Follow individual peptide safety guidelines for each component
- Use sterile technique for all injections
- Consult healthcare provider before combining multiple peptides