Spermidine — Supplements
Natural polyamine that induces autophagy and may mimic caloric restriction for cellular renewal.
Overview
Spermidine is a naturally occurring polyamine found in wheat germ, aged cheese, mushrooms, and soybeans that potently induces autophagy via inhibition of the acetyltransferase EP300. Autophagy is the cellular self-cleaning process essential for removing damaged organelles and misfolded proteins. Epidemiological data from the Bruneck Study (n=829, 20-year follow-up) showed an inverse association between dietary spermidine intake and all-cause mortality. Emerging clinical evidence supports cardioprotective and cognitive benefits through autophagy-mediated cellular renewal.
Indications
- Autophagy induction and cellular renewal
- Cardiovascular health and longevity
- Cognitive function preservation
- Healthy aging support
Mechanism of Action
Spermidine inhibits the acetyltransferase EP300, deacetylating cytoplasmic proteins and triggering autophagy
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Spermidine | 1 mg | Once daily | Wheat germ-derived preferred; emerging dosing; 1-2 mg/day studied |
Evidence Grade
GRADE B
Safety & Contraindications
- Generally well tolerated at dietary and low supplemental doses
- Limited human supplementation trial data for long-term safety
- Theoretical concern about polyamine promotion of cancer cell proliferation (not demonstrated clinically)
- Avoid in active malignancies until more safety data is available