Resveratrol — Supplements
Polyphenol stilbene activating sirtuins and mimicking caloric restriction for longevity and cardiometabolic benefits.
Overview
Resveratrol (3,5,4'-trihydroxystilbene) is a polyphenolic compound found in red grapes, berries, and peanuts that activates SIRT1 and mimics aspects of caloric restriction. It has demonstrated cardiovascular protection, anti-inflammatory effects, and improved insulin sensitivity in clinical trials. Meta-analyses show modest reductions in systolic blood pressure, fasting glucose, and inflammatory markers. Resveratrol has poor oral bioavailability; taking with fat-containing meals and combining with NMN may enhance its efficacy through synergistic sirtuin activation.
Indications
- Cardiovascular protection and endothelial function
- Sirtuin activation and longevity support
- Insulin sensitivity improvement
- Anti-inflammatory and antioxidant support
Mechanism of Action
Allosterically activates SIRT1, promoting deacetylation of PGC-1alpha, FOXO3, and p53 for mitochondrial biogenesis and stress resistance
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Resveratrol (trans-) | 500 mg | Once daily with fat-containing meal | Trans-resveratrol is the active isomer; take with NMN for synergy |
Evidence Grade
GRADE B
Safety & Contraindications
- GI side effects (diarrhea, nausea) at doses >1,000 mg/day
- Mild estrogenic activity; theoretical concern in estrogen-sensitive conditions
- May interact with CYP3A4 and CYP2D6 substrates
- Antiplatelet effects; caution with anticoagulants