Phytoceramides — Supplements
Plant-derived ceramide supplement supporting skin barrier function and moisture retention.
Overview
Phytoceramides are plant-derived sphingolipids (typically from wheat, rice, or sweet potato) structurally similar to endogenous ceramides that comprise 40-50% of skin barrier lipids. Oral supplementation aims to replenish ceramides systemically, supporting stratum corneum barrier function and moisture retention. Several small RCTs demonstrate improvements in skin hydration, transepidermal water loss (TEWL), and wrinkle depth after 4-12 weeks of supplementation. The evidence base is promising but still preliminary.
Indications
- Skin hydration and moisture retention
- Skin barrier function support
- Anti-aging skin care (wrinkle reduction)
Mechanism of Action
Orally ingested ceramides are absorbed and distributed to the skin via the bloodstream
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Phytoceramides | 40 mg | Once daily | Wheat, rice, or sweet potato-derived; 4-12 weeks for visible results |
Safety & Contraindications
- Generally well tolerated with no significant adverse effects reported
- Wheat-derived phytoceramides should be avoided in celiac disease or wheat allergy (gluten-free alternatives available)
- Limited long-term safety data
- Rice and sweet potato sources are gluten-free alternatives