Pentapeptide-18 (Leuphasyl) for Expression Line Reduction — Skin & Hair
Neurotransmitter-inhibiting peptide that reduces expression wrinkles through enkephalin-mimicking action.
Overview
Pentapeptide-18, marketed as Leuphasyl, is a pentapeptide that functions as a neurotransmitter inhibitor to reduce expression wrinkles. It mimics the action of natural enkephalins, modulating neurotransmitter release at the neuromuscular junction. This results in reduced muscle contraction and softer expression lines. Unlike Argireline which targets SNARE complexes, Pentapeptide-18 works through enkephalin receptor pathways, offering a complementary mechanism. Clinical studies show significant reduction in forehead wrinkles and crow's feet with topical application. It's particularly effective when combined with other anti-wrinkle peptides.
Indications
- Forehead wrinkles and expression lines
- Crow's feet and periorbital wrinkles
- Glabellar frown lines
- Expression wrinkle prevention
- Non-invasive Botox alternative
Mechanism of Action
Repeated facial expressions cause dynamic wrinkles through continuous muscle activation
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Pentapeptide-18 3-5% | Apply to forehead and eye area | Twice daily | Focus on areas with dynamic wrinkles |
| Pentapeptide-18 3% + Argireline 5% | Apply to expression lines | Once or twice daily | Dual neurotransmitter inhibition for enhanced effect |
Evidence Grade
GRADE C
Safety & Contraindications
- Well-tolerated in cosmetic formulations
- No systemic effects at topical doses
- Gentle on sensitive skin
- No neurotoxic concerns with topical use
- Safe for long-term cosmetic application
- Can be combined with Argireline for enhanced effect