Palmitoyl Tetrapeptide-7 for Anti-Inflammation & Skin Repair — Skin & Hair
Anti-inflammatory peptide that reduces IL-6 production and is a key component of Matrixyl 3000.
Overview
Palmitoyl Tetrapeptide-7 (previously Pal-GQPR) is an anti-inflammatory signal peptide and the second active component in Matrixyl 3000. It specifically reduces IL-6 production, a pro-inflammatory cytokine that accelerates skin aging. By reducing chronic low-grade inflammation (inflammaging), it protects existing collagen from degradation while allowing collagen synthesis to proceed. When combined with Palmitoyl Tripeptide-1, it creates a powerful dual-action system: stimulating new collagen while protecting existing collagen. Clinical studies demonstrate significant improvements in skin quality and wrinkle reduction.
Indications
- Chronic skin inflammation (inflammaging)
- UV-induced skin damage
- Collagen preservation and protection
- Sensitive or reactive skin types
- Age-related glycation damage
Mechanism of Action
Aging and UV exposure trigger IL-6 and inflammatory cytokine production, degrading collagen
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Palmitoyl Tetrapeptide-7 2% | Apply to face and neck | Twice daily | Typically combined with Palmitoyl Tripeptide-1 4% as Matrixyl 3000 |
| Palmitoyl Tetrapeptide-7 2-4% | Apply to inflamed or sensitive areas | Once or twice daily | Can be used standalone for anti-inflammatory benefits |
Safety & Contraindications
- Excellent safety and tolerability profile
- Particularly beneficial for sensitive skin types
- No adverse effects reported in clinical studies
- Can soothe irritation from other actives
- Safe for long-term daily use