Paleo Diet — Diets
Ancestral eating pattern based on presumed Paleolithic-era foods, emphasizing whole meats, vegetables, fruits, nuts, and excluding grains, legumes, and dairy.
Overview
The Paleolithic diet eliminates foods introduced after the agricultural revolution (grains, legumes, dairy, refined sugars, processed foods, seed oils) in favor of foods presumed to be consumed by Paleolithic humans (meat, fish, vegetables, fruits, nuts, seeds, tubers). Multiple RCTs demonstrate short-term benefits for weight loss, insulin sensitivity, blood pressure, and lipid profiles compared to standard dietary advice. A 2019 meta-analysis of 11 RCTs confirmed significant improvements in body weight, waist circumference, BMI, and blood pressure. However, long-term adherence data is limited, and concerns exist about calcium intake, fiber adequacy, and cost.
Indications
- Weight loss and body composition
- Insulin sensitivity improvement
- Blood pressure reduction
- Elimination of processed food intake
- Autoimmune condition support (via AIP variant)
Mechanism of Action
Removing refined grains, sugars, and seed oils reduces postprandial hyperglycemia, inflammatory omega-6 load, and caloric density
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Paleo Diet | Meat, fish, vegetables, fruits, nuts, seeds, tubers; no grains, legumes, dairy, sugar | Daily | Strict version excludes all non-Paleo foods; modified versions may include some dairy or rice |
Evidence Grade
GRADE C
Safety & Contraindications
- Calcium intake may be low without dairy; emphasize leafy greens and bone broth
- Higher meat intake may increase TMAO and saturated fat exposure
- Exclusion of legumes and whole grains removes important fiber and nutrient sources
- Cost of high-quality animal products may be prohibitive
- Long-term adherence and safety data are limited