NR Nicotinamide Riboside — Supplements

NAD+ precursor vitamin with demonstrated safety and efficacy for boosting cellular NAD+ levels.

Overview

Nicotinamide riboside (NR) is a form of vitamin B3 that serves as a precursor to NAD+ via the nicotinamide riboside kinase (NRK) pathway. NR is the most extensively studied oral NAD+ precursor in human clinical trials, with the NICE trial demonstrating functional improvement in peripheral artery disease patients. Multiple RCTs confirm that NR (250-1,000 mg/day) safely and significantly raises blood NAD+ levels. NR has FDA GRAS and NDI status, distinguishing it from NMN in regulatory clarity.

Indications

  • NAD+ repletion and cellular energy support
  • Cardiovascular health and vascular function
  • Healthy aging and longevity
  • Metabolic health optimization

Mechanism of Action

NR is phosphorylated by nicotinamide riboside kinase (NRK1/2) to form NMN

Dosing

CompoundDoseFrequencyNotes
Nicotinamide Riboside300 mgOnce daily (morning)Take in the AM; 250-1,000 mg studied in clinical trials

Evidence Grade

GRADE B

Safety & Contraindications

  • Well-tolerated in clinical trials up to 2,000 mg/day
  • Mild GI symptoms (nausea, bloating) reported at higher doses
  • No significant adverse effects in multiple Phase I/II trials
  • GRAS status provides higher regulatory confidence than some alternatives