NAD+ IV — Supplements
Intravenous nicotinamide adenine dinucleotide infusion for direct cellular NAD+ repletion.
Overview
Intravenous NAD+ therapy delivers nicotinamide adenine dinucleotide directly into the bloodstream, bypassing the rate-limited oral absorption and hepatic metabolism of NAD+ precursors. NAD+ is a critical coenzyme for mitochondrial energy production (sirtuins, PARPs) and declines significantly with age. IV administration rapidly elevates plasma NAD+ levels. Clinical applications include addiction recovery, neurodegenerative conditions, and anti-aging protocols. However, large-scale RCTs are limited, and the clinical superiority of IV NAD+ over oral precursors (NMN, NR) remains under investigation.
Indications
- NAD+ repletion for cellular energy
- Anti-aging and longevity protocols
- Addiction recovery support (adjunctive)
- Neurodegenerative disease support (adjunctive)
- Chronic fatigue management
Mechanism of Action
IV administration rapidly elevates plasma and cellular NAD+ levels bypassing oral bioavailability limitations
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| NAD+ (IV) | 250 mg | Weekly | 4-8 week course; dose range 250-1,000 mg per session |
Evidence Grade
GRADE C
Safety & Contraindications
- IV administration requires medical supervision and venous access
- Common side effects: chest tightness, nausea, flushing, and cramping during infusion
- Slow infusion rate (2-4 hours) minimizes adverse effects
- Cost-intensive; limited insurance coverage
- Not FDA-approved for any medical indication via IV route