Methyldrostanolone (Superdrol) for Extreme Lean Mass — Anabolic Steroids
Ultra-potent oral DHT derivative with extreme hepatotoxicity. Never approved for medical use.
Overview
Methyldrostanolone (Superdrol/Methasterone) is an extremely potent oral anabolic steroid that was sold as a 'designer steroid' supplement from 2005-2012 before being classified as Schedule III. It is structurally the 17-alpha-methylated version of Masteron (drostanolone), making it orally bioavailable but with extreme hepatotoxicity. Despite never being approved for any medical use, it has an impressive anabolic-to-androgenic ratio of approximately 400:20, making it highly selective for muscle tissue. Superdrol does NOT aromatize, producing dry, dense, hard muscle gains without water retention. It is considered the most hepatotoxic oral AAS available, with multiple published case reports of acute liver failure, cholestatic jaundice, and hospitalization. Gains of 10-15 lbs of lean mass in 3-4 weeks are reported, but the extreme liver toxicity limits use to very short cycles.
Indications
- Never approved for any medical indication
- Extreme lean mass accrual (non-medical)
- Rapid dry strength and mass gains
- Cosmetic muscle density and hardness
Mechanism of Action
Pursuit of rapid, dry, dense muscle gains with full acceptance of extreme hepatotoxicity risk (NOT medically indicated)
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Methyldrostanolone (Superdrol) | 10-20 mg | Once daily | Conservative dosing; still extreme hepatotoxicity. 3-4 weeks MAX |
| Methyldrostanolone (Superdrol) | 20-30 mg | Once or twice daily | Higher dosing with dramatically increased liver toxicity risk |
Evidence Grade
GRADE D
Safety & Contraindications
- NEVER approved for any medical use
- Schedule III controlled substance (US, classified 2012)
- EXTREME hepatotoxicity - most liver-toxic oral AAS available
- Multiple published case reports of acute liver failure and hospitalization
- Cholestatic jaundice documented in multiple patients
- Maximum cycle duration: 3-4 weeks ABSOLUTE MAXIMUM
- Liver support supplements mandatory (TUDCA, NAC)
- Complete avoidance of alcohol and all hepatotoxic substances
- Does NOT aromatize - no estrogenic side effects
- Severe HPTA suppression - robust PCT mandatory
- Lethargy and appetite loss common side effects (liver stress markers)
- Can cause acute renal failure (case reports)
- Cardiovascular: severe lipid deterioration and blood pressure elevation
- Dark urine and light stools are warning signs of liver damage - discontinue immediately