Mesterolone (Proviron) for Androgen & SHBG Modulation — Anabolic Steroids
Oral DHT derivative with strong androgenic and anti-estrogenic properties but minimal anabolic effect. Prescription medication.
Overview
Mesterolone (Proviron) is a unique oral DHT derivative introduced by Bayer/Schering in 1967. Unlike most oral AAS, it is NOT 17-alpha-alkylated, making it non-hepatotoxic. However, it is also one of the weakest anabolic agents due to rapid inactivation by 3-alpha-hydroxysteroid dehydrogenase (3alpha-HSD) in skeletal muscle. Its primary value lies in its strong androgenic effects and ability to significantly lower SHBG (sex hormone binding globulin), thereby increasing free testosterone. Proviron also has inherent anti-estrogenic properties and does not aromatize. It is one of the few AAS that causes minimal HPTA suppression at therapeutic doses. Medically prescribed for hypogonadism and male infertility (improves sperm quality and count), it remains available as a prescription medication in many countries.
Indications
- Male hypogonadism and androgen deficiency (prescription use)
- Male infertility - improves sperm quality and count
- SHBG reduction to increase free testosterone
- Anti-estrogenic support during testosterone therapy
- Libido enhancement in androgen-deficient males
- Adjunctive androgenic support
Mechanism of Action
Low free testosterone due to elevated SHBG, male infertility, or need for androgenic support without significant anabolic or estrogenic effects
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Mesterolone (Proviron) | 25-50 mg | 2-3 times daily | Standard prescription dosing for hypogonadism and infertility |
| Mesterolone (Proviron) | 25 mg | Once or twice daily | Adjunctive SHBG reduction and mild anti-estrogenic support |
Evidence Grade
GRADE C
Safety & Contraindications
- NOT 17-alpha-alkylated - NO hepatotoxicity (safe for liver)
- Prescription medication in many countries (not FDA-approved in US)
- Very weak anabolic effects - not effective for muscle building alone
- Strong androgenic effects: hair loss, acne, body hair possible
- Does NOT aromatize - no estrogenic side effects
- Minimal HPTA suppression at therapeutic doses
- Lowers SHBG significantly - increases free testosterone
- Can worsen androgenic alopecia due to DHT-derivative nature
- Monitor lipid profile - may negatively affect cholesterol
- Not recommended for women due to virilization risk at effective doses