Palmitoyl Tripeptide-38 (Matrixyl synthe'6) for Volume & Wrinkle Filling — Skin & Hair
Advanced Matrixyl peptide that fills wrinkles from within by stimulating 6 skin-rebuilding essentials.
Overview
Palmitoyl Tripeptide-38, marketed as Matrixyl synthe'6, is a third-generation Matrixyl peptide with a unique mechanism focused on volume restoration and wrinkle filling. Unlike earlier Matrixyl versions that primarily stimulate collagen, synthe'6 activates 6 major skin matrix constituents: collagen I, III, IV, fibronectin, hyaluronic acid, and laminin 5. This comprehensive approach fills wrinkles from within by rebuilding dermal architecture. Clinical studies show up to 31% reduction in wrinkle depth and 68% increase in wrinkle volume. It's particularly effective for mature skin with volume loss and deep wrinkles.
Indications
- Deep wrinkles with volume loss
- Age-related dermal thinning
- Loss of skin plumpness
- Nasolabial folds and marionette lines
- Comprehensive matrix restoration
Mechanism of Action
Aging causes decline in collagen, hyaluronic acid, and other matrix components, leading to wrinkles and volume loss
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Palmitoyl Tripeptide-38 2% | Apply to face, focusing on deep wrinkles | Twice daily | Standard dosing for wrinkle filling and volume restoration |
| Palmitoyl Tripeptide-38 2-4% | Apply to targeted deep wrinkle areas | Twice daily | Higher concentration for severe volume loss and deep lines |
Safety & Contraindications
- Excellent safety profile in clinical trials
- Well-tolerated across all skin types
- No adverse effects at cosmetic concentrations
- Compatible with other actives
- Safe for long-term daily use