Magnesium L-Threonate — Supplements
Patented magnesium form designed to cross the blood-brain barrier for cognitive and neurological applications.
Overview
Magnesium L-threonate (MgT, marketed as Magtein) was developed at MIT specifically to enhance brain magnesium levels by crossing the blood-brain barrier more effectively than other magnesium forms. Preclinical studies demonstrated significant increases in brain magnesium concentration, synaptic density, and cognitive function. A human RCT in older adults showed improvements in cognitive abilities equivalent to reversing brain age by 9 years. The threonate moiety (a vitamin C metabolite) facilitates magnesium transport across the BBB.
Indications
- Cognitive function and memory support
- Brain magnesium optimization
- Age-related cognitive decline prevention
- Sleep quality (secondary benefit)
Mechanism of Action
Threonate facilitates magnesium transport across the blood-brain barrier, increasing brain magnesium concentration
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Magnesium L-Threonate | 2,000 mg (providing ~144 mg elemental Mg) | Once daily (or split AM/PM) | Often taken in the evening; may need additional Mg form for systemic needs |
Safety & Contraindications
- Generally well tolerated; drowsiness reported by some users
- Lower elemental magnesium content per dose; may not address systemic magnesium deficiency alone
- May be combined with other magnesium forms for both brain and systemic benefits
- Limited long-term clinical data compared to other magnesium forms