Lion's Mane Mushroom — Supplements
Medicinal mushroom containing hericenones and erinacines that stimulate nerve growth factor synthesis.
Overview
Lion's mane (Hericium erinaceus) is a culinary-medicinal mushroom containing unique bioactive compounds: hericenones (from fruiting body) and erinacines (from mycelium) that stimulate nerve growth factor (NGF) synthesis. Preclinical studies demonstrate potent neurotropic and neuroprotective effects. A landmark RCT in older adults with mild cognitive impairment showed significant cognitive improvement during supplementation. Emerging evidence also supports benefits for depression, anxiety, and neuropathy, though large-scale clinical trials are still needed.
Indications
- Cognitive function and memory support
- Nerve growth factor stimulation
- Mood and anxiety support
- Neuroprotection and neuroregeneration
Mechanism of Action
Hericenones and erinacines cross the blood-brain barrier and stimulate nerve growth factor synthesis by astrocytes
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Lion's Mane Extract | 500 mg | 1-2 times daily | Dual extract (hot water + alcohol) from fruiting body preferred |
Safety & Contraindications
- Generally well tolerated; rare cases of GI discomfort or skin irritation
- Avoid in individuals with mushroom allergies
- May interact with anticoagulant and antiplatelet medications (theoretical)
- Limited long-term safety data in humans