L-Glutamine Gut Repair — Supplements
Targeted glutamine protocol for intestinal barrier repair and gut permeability restoration.
Overview
L-glutamine gut repair protocols utilize higher-dose, targeted glutamine supplementation specifically for intestinal barrier restoration. Glutamine is the primary fuel for enterocytes and is essential for maintaining tight junction proteins (claudins, occludin, ZO-1) that regulate intestinal permeability. Clinical studies in post-operative patients, critically ill individuals, and athletes demonstrate reduced intestinal permeability with glutamine supplementation. This protocol emphasizes fasted administration to maximize direct mucosal contact.
Indications
- Increased intestinal permeability (leaky gut)
- Post-antibiotic gut barrier restoration
- Exercise-induced GI stress
- IBS and functional GI disorder support
- Post-surgical GI recovery
Mechanism of Action
Glutamine upregulates expression of claudins, occludin, and ZO-1 proteins that seal intercellular junctions
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| L-Glutamine (Gut Repair) | 5 g | 2-3 times daily on empty stomach | Take 30 min before meals; 8-12 week repair protocol |
Safety & Contraindications
- Same safety profile as L-glutamine; avoid in hepatic encephalopathy
- Monitor for worsening symptoms during initial supplementation
- Combine with dietary interventions for comprehensive gut repair
- 8-12 week protocol with reassessment