L-Glutamine — Supplements
Conditionally essential amino acid supporting immune function, gut barrier integrity, and muscle recovery.
Overview
L-glutamine is the most abundant amino acid in plasma and skeletal muscle, serving as a primary fuel source for rapidly dividing cells including enterocytes, lymphocytes, and macrophages. During physiological stress (exercise, illness, surgery), glutamine demand may exceed endogenous synthesis, making it conditionally essential. Clinical evidence supports glutamine supplementation for gut barrier maintenance, immune function during heavy training, post-surgical recovery, and reduction of exercise-induced intestinal permeability.
Indications
- Gut barrier integrity and intestinal permeability
- Immune function during physiological stress
- Post-exercise recovery
- Critical illness nutritional support
Mechanism of Action
Glutamine is the primary metabolic fuel for intestinal epithelial cells, supporting proliferation and tight junction integrity
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| L-Glutamine | 5 g | 1-2 times daily | Dissolve in water; take on empty stomach or post-exercise |
Safety & Contraindications
- Generally well tolerated at doses up to 30 g/day in clinical settings
- Avoid in hepatic encephalopathy (may worsen ammonia accumulation)
- Some cancer researchers advise caution due to glutamine's role as a cancer cell fuel source
- May cause mild GI discomfort at high doses