Klotho for Anti-Aging and Neuroprotection — Aging
Anti-aging protein therapy for cognitive enhancement, kidney protection, and age-related decline prevention.
Overview
Klotho is an anti-aging protein that regulates multiple pathways involved in aging, including mineral metabolism, oxidative stress, and cellular senescence. Supplementation shows promise for cognitive enhancement, kidney protection, cardiovascular health, and healthy aging support. Named after the Greek goddess who spins the thread of life.
Indications
- Cognitive decline prevention and neuroprotection
- Age-related kidney function decline
- Cardiovascular health optimization
- Anti-aging and healthy aging enhancement
- Oxidative stress reduction
- Mineral metabolism support (calcium/phosphate balance)
Mechanism of Action
Klotho protein expression decreases with aging, impairing mineral metabolism and increasing oxidative stress
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Recombinant Klotho Protein | 10-20 mcg | 2-3x weekly | Standard emerging protocol for anti-aging applications |
| Klotho Peptide Fragment | 50-100 mcg | Once daily | Non-invasive route for neuroprotection and cognitive support |
| Klotho Peptide | 500-1000 mcg | Once daily | Oral bioavailability enhanced via liposomal delivery |
Evidence Grade
GRADE D
Safety & Contraindications
- Novel therapeutic approach with limited long-term human data
- Generally well-tolerated in early clinical studies
- May affect calcium and phosphate metabolism - monitor levels
- Use under medical supervision given emerging nature of therapy
- Avoid in hypercalcemia or severe kidney disease without physician guidance