Kisspeptin-10 for Sexual Desire & Reproductive Health — Libido & Sex
Novel neuropeptide for enhancing sexual desire, reproductive hormone secretion, and emotional-sexual brain processing.
Overview
Kisspeptin-10 is a naturally occurring neuropeptide that plays a crucial role in reproductive function and sexual desire. It stimulates GnRH (gonadotropin-releasing hormone) secretion, which in turn triggers LH and FSH release, boosting testosterone and estrogen production. Recent research shows it also enhances sexual and emotional brain processing, making it a promising therapeutic for sexual dysfunction and low libido.
Indications
- Low libido and hypoactive sexual desire
- Reproductive hormone optimization
- Enhanced sexual and emotional brain processing
- Adjunct for fertility enhancement
- Psychological sexual dysfunction
Mechanism of Action
Reduced GnRH secretion leads to low sex hormones and diminished sexual motivation
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Kisspeptin-10 | 1-4 nmol/kg (approx 0.1-0.3 mg for 70kg person) | 1-2 times weekly or as needed before activity | Enhances testosterone secretion and sexual desire |
| Kisspeptin-10 | 1-4 nmol/kg (approx 0.1-0.3 mg for 60kg person) | 1-2 times weekly or during follicular phase | Stimulates LH surge and enhances sexual motivation |
| Kisspeptin-10 | 0.5-1 mg | As needed, 1-2 hours before activity | Experimental route, direct CNS effects |
Evidence Grade
GRADE C
Safety & Contraindications
- Emerging peptide with limited but promising human data
- Generally well-tolerated in clinical trials
- May stimulate reproductive hormone axis (monitor hormone levels)
- Use sterile technique for all injections
- Not recommended during pregnancy