Iron Ferrous Bisglycinate — Supplements
Chelated iron form with superior absorption and reduced GI side effects for iron deficiency management.
Overview
Iron is an essential mineral required for hemoglobin synthesis, oxygen transport, and mitochondrial enzyme function. Ferrous bisglycinate is an amino acid chelate form of iron with superior bioavailability and significantly fewer GI side effects compared to ferrous sulfate or ferrous fumarate. The chelated structure protects iron from dietary inhibitors (phytates, tannins) and allows absorption via dipeptide transporters rather than DMT1 alone. Clinical trials demonstrate equivalent efficacy at lower elemental iron doses with improved tolerability.
Indications
- Iron deficiency anemia treatment
- Iron deficiency prevention in at-risk populations
- Pregnancy-related iron supplementation
- Athletes with exercise-induced iron depletion
Mechanism of Action
Amino acid chelation protects iron from dietary inhibitors and reduces oxidative damage to GI mucosa
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Iron (Ferrous Bisglycinate) | 25 mg elemental iron | Every other day (or as directed) | Take on empty stomach with vitamin C; every-other-day dosing may improve absorption |
Safety & Contraindications
- Iron overload (hemochromatosis) is a contraindication; check ferritin before supplementing
- Take every other day for improved fractional absorption (hepcidin cycling)
- May cause constipation, nausea, and dark stools (less common with bisglycinate)
- Accidental iron overdose is a leading cause of pediatric poisoning; store securely
- Separate from thyroid medications, calcium, and antacids by 2-4 hours