Green Tea Extract EGCG — Supplements
Catechin-rich extract with thermogenic, antioxidant, and cardiometabolic benefits.
Overview
Green tea extract is standardized to epigallocatechin gallate (EGCG), the most bioactive catechin polyphenol. EGCG inhibits catechol-O-methyltransferase (COMT) and phosphodiesterase, prolonging norepinephrine signaling and promoting thermogenesis and fat oxidation. Meta-analyses support modest body fat reduction, LDL cholesterol lowering, and blood pressure improvement. EGCG also demonstrates anti-cancer properties in preclinical models via cell cycle arrest and apoptosis induction.
Indications
- Fat oxidation and thermogenesis
- Cardiovascular risk factor improvement
- Antioxidant and anti-inflammatory support
- Metabolic health optimization
Mechanism of Action
EGCG inhibits catechol-O-methyltransferase, prolonging norepinephrine activity and sympathetic-mediated thermogenesis
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Green Tea Extract (EGCG) | 400 mg | Once daily | Standardized to 50% EGCG; take with food; cycle 8-12 weeks |
Evidence Grade
GRADE C
Safety & Contraindications
- Hepatotoxicity reported with high-dose concentrated extracts (>800 mg EGCG/day)
- Take with food to reduce liver toxicity risk and improve tolerability
- Caffeine content may cause insomnia, anxiety, or tachycardia in sensitive individuals
- May reduce iron absorption; separate from iron supplements by 2 hours
- Cycle 8-12 weeks on, then reassess