Ginger Extract — Supplements
Bioactive gingerol-rich extract with antiemetic, anti-inflammatory, and digestive health properties.
Overview
Ginger (Zingiber officinale) extract contains bioactive compounds including gingerols, shogaols, and zingerone with well-documented antiemetic, anti-inflammatory, and prokinetic properties. The antiemetic mechanism involves 5-HT3 receptor antagonism in the GI tract. Cochrane reviews and meta-analyses support its efficacy for nausea and vomiting of pregnancy, chemotherapy-induced nausea, and motion sickness. Additional evidence supports anti-inflammatory effects comparable to NSAIDs for osteoarthritis and dysmenorrhea.
Indications
- Nausea and vomiting (pregnancy, chemotherapy, post-operative)
- Motion sickness prevention
- Digestive comfort and motility
- Anti-inflammatory support (osteoarthritis, dysmenorrhea)
Mechanism of Action
Gingerols and shogaols block serotonin 5-HT3 receptors in the GI tract and chemoreceptor trigger zone
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Ginger Extract | 250 mg | 1-4 times daily | Standardized to gingerol content; 250 mg QID for nausea |
Safety & Contraindications
- Generally recognized as safe; mild heartburn possible at higher doses
- May have mild antiplatelet effects; exercise caution before surgery
- Safe in pregnancy at recommended doses (< 1,500 mg/day) per ACOG
- May interact with anticoagulant medications