Fasting Mimicking Diet (FMD) — Diets
Periodic 5-day low-calorie plant-based protocol designed to mimic fasting physiology while allowing food intake.
Overview
The Fasting Mimicking Diet (FMD), developed by Valter Longo at USC, is a 5-day low-calorie, low-protein, high-fat plant-based protocol providing ~1,100 kcal on day 1 and ~800 kcal on days 2-5. It is designed to trigger fasting-like metabolic changes (reduced IGF-1, elevated ketones, autophagy) while allowing food consumption. Multiple clinical trials (including the landmark 2017 Science Translational Medicine study) demonstrate benefits for body composition, blood pressure, CRP, IGF-1, fasting glucose, and biological age markers. Monthly cycles (5 days per month for 3 consecutive months) are the standard protocol.
Indications
- Biological age reduction
- Cardiometabolic risk factor improvement
- IGF-1 and growth factor reduction
- Stem cell-based regeneration
- Body composition improvement
Mechanism of Action
Low protein and calorie intake reduces circulating IGF-1 and insulin, mimicking the hormonal milieu of water fasting
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Fasting Mimicking Diet | ~1,100 kcal day 1; ~800 kcal days 2-5 | 5 consecutive days per month for 3 months | High fat, low protein, plant-based; ProLon is the commercial kit |
Evidence Grade
GRADE C
Safety & Contraindications
- Fatigue, headaches, and weakness are common during the 5-day cycle
- Not recommended for individuals with BMI < 18.5 or eating disorders
- Diabetic patients require medical supervision and medication adjustment
- Gradual return to normal diet after each cycle to avoid GI distress
- Consult physician if on blood pressure or diabetes medications