Epigenetic Age Testing (TruDiagnostic, Elysium Index) — Diagnostics & Biomarker Testing
Commercial biological age testing services providing multiple epigenetic clock measurements, pace-of-aging assessment, and longitudinal tracking to guide longevity interventions.
Overview
TruDiagnostic's TruAge Complete and Elysium Health's Index are the leading commercial epigenetic age testing platforms, both using Illumina EPIC array methylation profiling on blood samples. TruAge Complete provides Horvath clock, GrimAge, PhenoAge, DunedinPACE, and telomere length estimates from a single blood draw. It also includes organ-specific age estimates for brain, heart, liver, kidney, immune, and metabolic systems. Elysium Index focuses primarily on DunedinPACE. Morgan Levine (Yale, formerly Calico) developed PhenoAge, trained on clinical biomarkers to predict mortality. The tests cost $299-500 and are increasingly used in clinical longevity programs and research trials to objectively measure aging rate changes. Bryan Johnson's Blueprint team uses regular biological age testing as a core metric of their intervention program. A growing body of research shows lifestyle interventions can meaningfully change biological age clock readings within 6-12 months.
Indications
- Biological age estimation with multiple validated algorithms
- Longevity intervention response monitoring
- Organ-specific aging assessment
- Pace of aging tracking (DunedinPACE)
- Baseline establishment before starting longevity protocols
Mechanism of Action
Illumina EPIC array measures DNA methylation at 850,000+ CpG sites from a single blood sample, providing the raw methylation data that multiple clock algorithms then analyze
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| TruAge Complete (TruDiagnostic) | Blood draw (venipuncture or dried spot) | Every 6-12 months | $499 complete panel; includes 6+ clocks, organ ages, telomere length |
| Elysium Index | Dried blood spot card | Every 6-12 months | $299 single test; DunedinPACE-focused |
Evidence Grade
GRADE B
Safety & Contraindications
- Blood draw with standard risks; dried blood spot option available for home collection
- Results can cause anxiety if biological age is significantly older than chronological age
- Clocks are population-level predictors — individual variation is high
- Not clinically validated for individual diagnosis or treatment decisions