Curcumin with Piperine — Supplements
Bioenhanced turmeric extract with broad-spectrum anti-inflammatory and antioxidant properties.
Overview
Curcumin is the principal curcuminoid in turmeric (Curcuma longa) with potent anti-inflammatory effects mediated through NF-kB inhibition, COX-2 suppression, and modulation of multiple inflammatory signaling cascades. Native curcumin has poor oral bioavailability (<1%) due to rapid hepatic metabolism and poor absorption. Co-administration with piperine (from black pepper) inhibits glucuronidation and increases curcumin bioavailability by 2,000%. RCTs demonstrate efficacy comparable to NSAIDs for osteoarthritis pain and improvements in metabolic and inflammatory markers.
Indications
- Osteoarthritis and joint inflammation
- Systemic inflammation reduction
- Metabolic syndrome support
- Exercise-induced muscle soreness
- Mood and cognitive support
Mechanism of Action
Curcumin inhibits IKK-mediated NF-kB activation, reducing transcription of pro-inflammatory genes
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Curcumin with Piperine | 500 mg | 1-2 times daily | Standardized to 95% curcuminoids with 5 mg piperine per dose |
Safety & Contraindications
- GI side effects (nausea, diarrhea) at high doses
- Piperine inhibits CYP3A4 and P-glycoprotein; significant drug interaction potential
- May increase bleeding risk; use caution with anticoagulants
- Rare liver injury reports with high-dose, long-term use
- Avoid during pregnancy in supplemental doses