Citrulline Malate — Supplements
Amino acid precursor to arginine that enhances nitric oxide production and exercise performance.
Overview
L-citrulline malate combines the amino acid L-citrulline with malic acid. Citrulline is converted to arginine in the kidneys, providing a more effective means of raising plasma arginine and nitric oxide levels than direct arginine supplementation (which undergoes extensive first-pass metabolism). Malate contributes to the TCA cycle as an anaplerotic substrate. Studies demonstrate improvements in exercise performance, reduced post-exercise soreness, and enhanced blood flow. Evidence is strongest for resistance exercise performance.
Indications
- Exercise performance enhancement (resistance and endurance)
- Nitric oxide and blood flow augmentation
- Post-exercise muscle soreness reduction
- Ammonia clearance and urea cycle support
Mechanism of Action
Citrulline is converted to arginine via argininosuccinate synthase and lyase in the kidneys
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Citrulline Malate (2:1) | 6 g | 30-60 min pre-exercise | 2:1 citrulline:malate ratio; as needed for exercise sessions |
| L-Citrulline (pure) | 3 g | Twice daily | For cardiovascular / blood pressure indications |
Evidence Grade
GRADE C
Safety & Contraindications
- Generally well tolerated; mild GI discomfort possible at higher doses
- May potentiate effects of blood pressure medications or PDE5 inhibitors
- No significant adverse effects reported in clinical studies up to 8 g/day
- Avoid combining with nitrate-based medications