Caloric Restriction Mimetics Diet — Diets
Dietary strategy incorporating natural compounds that activate CR pathways (AMPK, sirtuins, autophagy) without actual caloric reduction.
Overview
Caloric restriction mimetics (CRMs) are dietary compounds that activate the same molecular pathways as caloric restriction (AMPK, sirtuins, autophagy, mTOR inhibition) without reducing calorie intake. Key CRMs include resveratrol (SIRT1 activator), spermidine (autophagy inducer), metformin/berberine (AMPK activators), rapamycin (mTOR inhibitor, prescription), and polyphenol-rich foods. The CRM dietary strategy involves incorporating foods and beverages naturally rich in these compounds: red wine, green tea, coffee, berries, turmeric, broccoli sprouts (sulforaphane), dark chocolate, and fermented foods (spermidine). This represents a food-first approach to longevity pathway activation, though direct supplementation may provide more reliable dosing.
Indications
- Longevity pathway activation through diet
- Autophagy enhancement without fasting
- Metabolic health optimization
- Complementary approach to intermittent fasting
Mechanism of Action
CRM-rich foods activate AMPK, SIRT1, and Nrf2 pathways while inhibiting mTORC1, mimicking the molecular signature of caloric restriction
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| CR Mimetics Diet | Green tea 3-5 cups/day; berries daily; turmeric daily; broccoli sprouts 3x/week; dark chocolate 20-30g/day | Daily incorporation of CRM-rich foods | Food-first approach; supplements (NMN, resveratrol, spermidine) as adjuncts |
Safety & Contraindications
- Individual food compounds are generally safe at dietary doses
- Drug-nutrient interactions possible (e.g., resveratrol with blood thinners)
- Excessive green tea may affect iron absorption
- Combining multiple CRMs at high doses has unknown interaction profiles
- Not a substitute for proven lifestyle interventions (CR, exercise)