Betaine TMG — Supplements
Trimethylglycine serving as a methyl donor for homocysteine metabolism and osmolyte for cellular protection.
Overview
Betaine (trimethylglycine, TMG) is a naturally occurring osmolyte and methyl donor derived from choline oxidation. It donates methyl groups to homocysteine via betaine-homocysteine methyltransferase (BHMT), supporting the methionine cycle and reducing homocysteine levels. As an osmolyte, betaine protects cells against osmotic stress. Moderate evidence supports its use for homocysteine reduction, exercise performance, and body composition improvement.
Indications
- Homocysteine reduction
- Methylation support
- Exercise performance and power output
- Body composition optimization
- Liver health and lipid metabolism
Mechanism of Action
Donates a methyl group to homocysteine via BHMT, regenerating methionine
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Betaine TMG | 2,500 mg | Once daily | Take with food; can split into 2 doses |
Evidence Grade
GRADE C
Safety & Contraindications
- Generally well tolerated with minimal side effects
- May cause GI discomfort (nausea, diarrhea) at higher doses
- Fishy body odor possible due to trimethylamine production
- Monitor cholesterol in hyperlipidemic patients (may raise LDL in some)