B-Complex — Supplements
Comprehensive B-vitamin formulation supporting energy metabolism, methylation, and neurological function.
Overview
B-complex supplements contain all eight essential B vitamins (B1, B2, B3, B5, B6, B7, B9, B12) that serve as critical cofactors in energy metabolism, DNA synthesis, methylation, and neurological function. Deficiency in any B vitamin can cause significant clinical consequences. Strong evidence supports supplementation in populations at risk for deficiency including older adults, vegetarians, those with malabsorption, and individuals on certain medications.
Indications
- Energy metabolism support
- Methylation and homocysteine management
- Neurological function and mood support
- Deficiency prevention in at-risk populations
- Prenatal nutritional support (folate)
Mechanism of Action
B vitamins serve as essential cofactors in >100 enzymatic reactions across energy, amino acid, and nucleotide metabolism
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| B-Complex | 1 capsule | Once daily | Take with food to improve absorption and reduce nausea |
Evidence Grade
GRADE C
Safety & Contraindications
- High-dose B6 (>100 mg/day) can cause peripheral neuropathy
- Niacin (B3) may cause flushing at pharmacological doses
- Bright yellow urine (riboflavin) is harmless and expected
- Consult healthcare provider if on levodopa, methotrexate, or phenytoin