Autoimmune Protocol (AIP) — Diets
Therapeutic elimination diet targeting immune system modulation by removing foods that may trigger intestinal permeability and immune activation.
Overview
The Autoimmune Protocol (AIP) is a therapeutic elimination diet that removes foods theorized to increase intestinal permeability and immune activation in individuals with autoimmune conditions. The elimination phase removes grains, legumes, dairy, eggs, nuts, seeds, nightshades, alcohol, refined sugars, and food additives. After 30-90 days, foods are systematically reintroduced to identify individual triggers. Clinical studies in IBD (Crohn's and ulcerative colitis) and Hashimoto's thyroiditis have demonstrated clinical remission in a significant percentage of participants. A 2017 study showed 73% of IBD patients achieved clinical remission on AIP.
Indications
- Autoimmune disease management (IBD, Hashimoto's, RA, MS, psoriasis)
- Food sensitivity identification
- Intestinal permeability reduction
- Chronic inflammatory condition support
Mechanism of Action
Removal of common immune-stimulating foods reduces antigen presentation and intestinal immune activation
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| AIP Elimination Phase | Remove grains, legumes, dairy, eggs, nuts, seeds, nightshades, alcohol | Daily for 30-90 days | Eat: meat, fish, vegetables (non-nightshade), fruit, healthy fats |
| AIP Reintroduction Phase | One food group every 5-7 days | Systematic reintroduction | Track symptoms for each reintroduced food; keep food diary |
Evidence Grade
GRADE C
Safety & Contraindications
- Highly restrictive; risk of nutritional inadequacy if not well-planned
- Elimination phase should not exceed 90 days without reintroduction
- May exacerbate disordered eating patterns in susceptible individuals
- Professional guidance from registered dietitian recommended
- Not a replacement for prescribed autoimmune medications