Ashwagandha KSM-66 — Supplements
Standardized root extract adaptogen with demonstrated cortisol-lowering and anxiolytic properties.
Overview
Ashwagandha (Withania somnifera) KSM-66 is a full-spectrum root extract standardized to 5% withanolides. It functions as an adaptogen by modulating the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol levels, and enhancing stress resilience. Multiple RCTs demonstrate significant improvements in perceived stress, anxiety, sleep quality, and testosterone levels in men. KSM-66 also shows ergogenic properties including improved VO2max and strength.
Indications
- Stress and anxiety management
- Cortisol reduction
- Sleep quality improvement
- Testosterone support in males
- Exercise performance enhancement
Mechanism of Action
Withanolides attenuate cortisol secretion by modulating the hypothalamic-pituitary-adrenal axis
Dosing
| Compound | Dose | Frequency | Notes |
|---|---|---|---|
| Ashwagandha KSM-66 | 600 mg | Once daily | Standardized to 5% withanolides; take with food |
| Ashwagandha KSM-66 | 300 mg | Twice daily | Split dosing for sustained effect |
Safety & Contraindications
- Cycle 8-12 weeks on, 2-4 weeks off recommended
- May potentiate thyroid hormone levels; monitor in thyroid disorders
- Avoid in autoimmune conditions due to immune-stimulatory effects
- May potentiate sedative medications
- Not recommended during pregnancy or lactation