Thymosin Beta-4 — Actin-sequestering peptide — wound healing
Sequesters G-actin to regulate cytoskeleton reorganization, promotes cell migration, angiogenesis, and anti-inflammatory pathways. Upregulates Wnt/β-catenin signaling for tissue repair. Reduces inflammatory cytokines.
Overview
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Compound Class
Actin-sequestering peptide — wound healing
Mechanism of Action
Sequesters G-actin to regulate cytoskeleton reorganization, promotes cell migration, angiogenesis, and anti-inflammatory pathways. Upregulates Wnt/β-catenin signaling for tissue repair. Reduces inflammatory cytokines.
Regulatory Status
Not FDA approved; orphan drug designation for epidermolysis bullosa
Evidence Level
Moderate — Phase 2 cardiac trials; primarily preclinical data for other indications