Thymalin — Khavinson thymic polypeptide bioregulator / immune regulator
Thymalin is a polypeptide complex extracted from bovine thymus gland. Its active dipeptide component Thymagen (Lys-Glu) restores T-cell maturation, normalizes CD4/CD8 ratios, enhances NK cell activity, and reactivates immune gene expression programs that decline with aging. Different from Thymosin Alpha-1 (which is a defined 28-amino acid peptide). Thymalin works via epigenetic gene regulation pathways at the chromatin level.
Overview
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Compound Class
Khavinson thymic polypeptide bioregulator / immune regulator
Mechanism of Action
Thymalin is a polypeptide complex extracted from bovine thymus gland. Its active dipeptide component Thymagen (Lys-Glu) restores T-cell maturation, normalizes CD4/CD8 ratios, enhances NK cell activity, and reactivates immune gene expression programs that decline with aging. Different from Thymosin Alpha-1 (which is a defined 28-amino acid peptide). Thymalin works via epigenetic gene regulation pathways at the chromatin level.
Regulatory Status
Not FDA approved. Russian pharmaceutical drug (Thymalin injection). Approved in Russia for immunodeficiency and post-chemotherapy immune recovery.
Evidence Level
Moderate — multiple published clinical studies (n=266 longitudinal, 15-year follow-up; COVID-19 trial n=36; immunodeficiency studies). Data primarily from Khavinson's group.