Testosterone — Androgen / Anabolic-Androgenic Steroid (AAS)
Binds androgen receptors (AR) to regulate gene transcription affecting muscle protein synthesis, bone density, erythropoiesis, libido, mood, and metabolic function. Aromatizes to estradiol via aromatase enzyme. Reduces via 5α-reductase to DHT.
Overview
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Compound Class
Androgen / Anabolic-Androgenic Steroid (AAS)
Mechanism of Action
Binds androgen receptors (AR) to regulate gene transcription affecting muscle protein synthesis, bone density, erythropoiesis, libido, mood, and metabolic function. Aromatizes to estradiol via aromatase enzyme. Reduces via 5α-reductase to DHT.
Regulatory Status
FDA approved (Schedule III controlled substance)
Evidence Level
High — decades of clinical use, multiple RCTs, FDA-approved indications