Progesterone — Steroid hormone — progestogen
Binds progesterone receptors (PR) to regulate endometrial receptivity, maintain pregnancy, modulate immune function, and act as neurosteroid (metabolite allopregnanolone enhances GABA-A receptor activity for calming/sleep effects).
Overview
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Compound Class
Steroid hormone — progestogen
Mechanism of Action
Binds progesterone receptors (PR) to regulate endometrial receptivity, maintain pregnancy, modulate immune function, and act as neurosteroid (metabolite allopregnanolone enhances GABA-A receptor activity for calming/sleep effects).
Regulatory Status
FDA approved (multiple formulations)
Evidence Level
High — FDA-approved; extensive clinical use in HRT and fertility