Pregnenolone — Neurosteroid / steroid hormone precursor
Master precursor steroid synthesized from cholesterol. Converts to progesterone, DHEA, cortisol, testosterone, and estradiol via enzymatic pathways. Independently acts as a neurosteroid enhancing GABA and NMDA receptor function for cognitive and mood benefits.
Overview
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Compound Class
Neurosteroid / steroid hormone precursor
Mechanism of Action
Master precursor steroid synthesized from cholesterol. Converts to progesterone, DHEA, cortisol, testosterone, and estradiol via enzymatic pathways. Independently acts as a neurosteroid enhancing GABA and NMDA receptor function for cognitive and mood benefits.
Regulatory Status
Available as dietary supplement (not FDA-regulated as drug)
Evidence Level
Low-Moderate — limited RCTs; primarily clinical observation and preclinical data