Pinealon — Khavinson tripeptide bioregulator — brain / neuroprotective
Pinealon (Glu-Asp-Arg) is a tripeptide targeting brain tissue. Proposed to enter neurons and activate tissue-specific neuroprotective gene expression programs. In the TBI clinical study (n=72), improved memory, attention, and EEG bioelectric activity. Animal studies show reduced caspase-3 activity, normalized NMDA receptor expression, and protection from oxidative stress. Crosses the blood-brain barrier due to its small size.
Overview
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Compound Class
Khavinson tripeptide bioregulator — brain / neuroprotective
Mechanism of Action
Pinealon (Glu-Asp-Arg) is a tripeptide targeting brain tissue. Proposed to enter neurons and activate tissue-specific neuroprotective gene expression programs. In the TBI clinical study (n=72), improved memory, attention, and EEG bioelectric activity. Animal studies show reduced caspase-3 activity, normalized NMDA receptor expression, and protection from oxidative stress. Crosses the blood-brain barrier due to its small size.
Regulatory Status
Not FDA approved. Available as research peptide. Not approved as pharmaceutical in Russia either (supplement/research status).
Evidence Level
Low-Moderate — Clinical study n=72 TBI patients (improved cognition); preclinical animal data; primarily Khavinson group publications.