MOTS-c — Mitochondria-derived peptide (MDP)
Activates AMPK pathway, enhances glucose metabolism and insulin sensitivity, promotes fatty acid oxidation, improves mitochondrial function, and has exercise-mimetic effects on skeletal muscle via nuclear translocation and gene regulation.
Overview
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Compound Class
Mitochondria-derived peptide (MDP)
Mechanism of Action
Activates AMPK pathway, enhances glucose metabolism and insulin sensitivity, promotes fatty acid oxidation, improves mitochondrial function, and has exercise-mimetic effects on skeletal muscle via nuclear translocation and gene regulation.
Regulatory Status
Not FDA approved; research peptide
Evidence Level
Low-Moderate — emerging clinical data; primarily preclinical