Kisspeptin — Hypothalamic neuropeptide
Binds KISS1R (GPR54) on GnRH neurons to stimulate pulsatile GnRH release, which drives LH/FSH secretion. Master regulator of reproductive axis initiation and function. Also influences metabolic signaling and psychosexual processing.
Overview
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Compound Class
Hypothalamic neuropeptide
Mechanism of Action
Binds KISS1R (GPR54) on GnRH neurons to stimulate pulsatile GnRH release, which drives LH/FSH secretion. Master regulator of reproductive axis initiation and function. Also influences metabolic signaling and psychosexual processing.
Regulatory Status
Not FDA approved; investigational
Evidence Level
Moderate — Phase 2 trials for IVF; extensive mechanistic research