GH (Growth Hormone) — Peptide hormone — 191 amino acid polypeptide
Binds GH receptor (GHR), activates JAK2-STAT5 signaling. Stimulates hepatic IGF-1 production. Promotes lipolysis, protein synthesis, bone growth, and cellular regeneration. Antagonizes insulin action on glucose metabolism.
Overview
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Compound Class
Peptide hormone — 191 amino acid polypeptide
Mechanism of Action
Binds GH receptor (GHR), activates JAK2-STAT5 signaling. Stimulates hepatic IGF-1 production. Promotes lipolysis, protein synthesis, bone growth, and cellular regeneration. Antagonizes insulin action on glucose metabolism.
Regulatory Status
FDA approved (various indications); off-label use common
Evidence Level
High — FDA-approved with decades of clinical data