Rhodiola Rosea — Adaptogen / botanical
Rhodiola rosea is an arctic adaptogenic root standardized to rosavins (3%) and salidroside (1%) (SHR-5 extract in most RCTs). Mechanisms: (1) HPA axis modulation — reduces cortisol response to stress; (2) Inhibits MAO-A and MAO-B (mild antidepressant-like); (3) Stimulates serotonin and dopamine synthesis; (4) Anti-fatigue via ATP synthesis enhancement in mitochondria; (5) Increases β-endorphins; (6) AMPK activation with metabolic effects. Adaptogen category: non-specific resistance — increases tolerance to physical, chemical, and biological stressors. Unlike stimulants, does not deplete reserves.
نظرة عامة
هذه الصفحة جزء من مكتبة المركّبات المُصنَّفة بالأدلة في Hormonaly. جميع الادعاءات السريرية مرتبطة بمصادر علمية مُحكَّمة عبر خط أنابيب التحقق المزدوج للاستشهادات.
فئة المركّب
Adaptogen / botanical
آلية العمل
Rhodiola rosea is an arctic adaptogenic root standardized to rosavins (3%) and salidroside (1%) (SHR-5 extract in most RCTs). Mechanisms: (1) HPA axis modulation — reduces cortisol response to stress; (2) Inhibits MAO-A and MAO-B (mild antidepressant-like); (3) Stimulates serotonin and dopamine synthesis; (4) Anti-fatigue via ATP synthesis enhancement in mitochondria; (5) Increases β-endorphins; (6) AMPK activation with metabolic effects. Adaptogen category: non-specific resistance — increases tolerance to physical, chemical, and biological stressors. Unlike stimulants, does not deplete reserves.
الوضع التنظيمي
OTC dietary supplement. Traditional Herbal Medicinal Product (THMP) status in some EU countries.
مستوى الأدلة
Moderate — multiple RCTs for fatigue, stress, and performance. Swedish Agency for Medicinal Products approved SHR-5 for fatigue in Europe (traditional herbal medicinal product). No US guidelines.