Magnesium Glycinate — Essential mineral / cofactor
Magnesium is a cofactor in >300 enzymatic reactions including ATP synthesis, DNA replication/repair, protein synthesis, and muscle contraction. Acts as physiologic calcium antagonist at NMDA receptors (anxiolytic, anticonvulsant, sleep-promoting). Required for Vitamin D hydroxylation (CYP27B1). Regulates insulin receptor signaling (insulin resistance is worsened by deficiency). Supports HPA axis regulation. Estimated 50–75% of Americans are deficient by RDA. Glycinate form chelated with glycine — superior bioavailability and tolerability vs. oxide; also provides glycine's calming effects. L-Threonate form uniquely crosses blood-brain barrier; studied for synaptic plasticity and cognitive function.
نظرة عامة
هذه الصفحة جزء من مكتبة المركّبات المُصنَّفة بالأدلة في Hormonaly. جميع الادعاءات السريرية مرتبطة بمصادر علمية مُحكَّمة عبر خط أنابيب التحقق المزدوج للاستشهادات.
فئة المركّب
Essential mineral / cofactor
آلية العمل
Magnesium is a cofactor in >300 enzymatic reactions including ATP synthesis, DNA replication/repair, protein synthesis, and muscle contraction. Acts as physiologic calcium antagonist at NMDA receptors (anxiolytic, anticonvulsant, sleep-promoting). Required for Vitamin D hydroxylation (CYP27B1). Regulates insulin receptor signaling (insulin resistance is worsened by deficiency). Supports HPA axis regulation. Estimated 50–75% of Americans are deficient by RDA. Glycinate form chelated with glycine — superior bioavailability and tolerability vs. oxide; also provides glycine's calming effects. L-Threonate form uniquely crosses blood-brain barrier; studied for synaptic plasticity and cognitive function.
الوضع التنظيمي
OTC dietary supplement. No prescription form except IV magnesium sulfate (hospital use).
مستوى الأدلة
Moderate-High — multiple RCTs support sleep improvement (MMSE scores), migraine prevention, and glycemic control. Deficiency strongly linked to clinical outcomes.