Liraglutide — GLP-1 receptor agonist (daily injection)

Liraglutide produces ~6-8% weight loss from baseline (Saxenda), compared to ~15% for semaglutide 2.4mg (Wegovy) and ~22% for tirzepatide 15mg. The lower efficacy is partly due to daily vs weekly dosing (less sustained receptor activation) and absence of GIP agonism. LEADER trial (2016) was the first GLP-1 trial to demonstrate CV mortality reduction, establishing the cardiovascular rationale for the entire drug class. Discontinuation rates are higher than semaglutide due to frequent daily injections.

نظرة عامة

هذه الصفحة جزء من مكتبة المركّبات المُصنَّفة بالأدلة في Hormonaly. جميع الادعاءات السريرية مرتبطة بمصادر علمية مُحكَّمة عبر خط أنابيب التحقق المزدوج للاستشهادات.

فئة المركّب

GLP-1 receptor agonist (daily injection)

آلية العمل

Liraglutide is a fatty-acid acylated GLP-1 analog with 97% sequence homology to native GLP-1. The C-16 fatty acid chain enables albumin binding, extending half-life from ~2 minutes (native GLP-1) to ~13 hours, enabling once-daily dosing. Activates GLP-1 receptors in pancreatic β-cells (glucose-dependent insulin secretion), hypothalamic appetite centers (reduces energy intake ~500 kcal/day), brainstem (nausea/satiety signaling), and GI tract (slows gastric emptying). Cardioprotective mechanism: anti-inflammatory effects on coronary vasculature, reduced platelet aggregation, and direct GLP-1 receptor effects in cardiomyocytes — demonstrated in LEADER trial (13% MACE reduction). Predates semaglutide; used to establish GLP-1 agonist cardiovascular safety profile.

الوضع التنظيمي

FDA approved — Victoza (T2DM, 2010), Saxenda (obesity, 2014)

مستوى الأدلة

High — SCALE Phase 3 program (weight), LEADER trial (cardiovascular outcomes in T2DM)