HCG — Gonadotropin / LH analog
Human chorionic gonadotropin (hCG) is a glycoprotein hormone structurally homologous to LH (luteinizing hormone), sharing the same alpha subunit and binding the LH/CG receptor (LHCGR) on testicular Leydig cells and ovarian theca cells. In men: activates Leydig cells → testosterone and estradiol production + maintains intratesticular testosterone (ITT) levels essential for spermatogenesis. Key clinical application: during TRT, exogenous testosterone suppresses LH/FSH → Leydig cells atrophy → ITT falls 95%+ → spermatogenesis impairs. hCG supplementation maintains ITT and prevents Leydig cell atrophy, preserving fertility. Also prevents testicular atrophy (volume). In women: triggers ovulation (LH surge mimic) in ART cycles; used as pregnancy support in luteal phase.
نظرة عامة
هذه الصفحة جزء من مكتبة المركّبات المُصنَّفة بالأدلة في Hormonaly. جميع الادعاءات السريرية مرتبطة بمصادر علمية مُحكَّمة عبر خط أنابيب التحقق المزدوج للاستشهادات.
فئة المركّب
Gonadotropin / LH analog
آلية العمل
Human chorionic gonadotropin (hCG) is a glycoprotein hormone structurally homologous to LH (luteinizing hormone), sharing the same alpha subunit and binding the LH/CG receptor (LHCGR) on testicular Leydig cells and ovarian theca cells. In men: activates Leydig cells → testosterone and estradiol production + maintains intratesticular testosterone (ITT) levels essential for spermatogenesis. Key clinical application: during TRT, exogenous testosterone suppresses LH/FSH → Leydig cells atrophy → ITT falls 95%+ → spermatogenesis impairs. hCG supplementation maintains ITT and prevents Leydig cell atrophy, preserving fertility. Also prevents testicular atrophy (volume). In women: triggers ovulation (LH surge mimic) in ART cycles; used as pregnancy support in luteal phase.
الوضع التنظيمي
FDA-approved (Pregnyl, Novarel, Ovidrel for fertility). Compounded hCG widely used in TRT protocols. Note: FDA issued 2020 guidance restricting bulk powder compounding — pharmacy-compounded hCG still available under different regulations.
مستوى الأدلة
High — FDA-approved for multiple indications. Decades of clinical use in reproductive medicine. Endocrine Society guidelines support as adjunct to TRT for fertility preservation.