GHK-Cu — Copper-binding tripeptide / wound-healing peptide
GHK-Cu (glycyl-l-histidyl-l-lysine complexed with copper) activates over 4,000 genes involved in tissue remodeling. Stimulates collagen, elastin, and glycosaminoglycan synthesis. Activates stem cells and TGF-β1 pathways. Anti-inflammatory via down-regulation of NF-κB. Promotes angiogenesis through VEGF and FGF-2. Copper chelation activity modulates metalloproteinase activity (MMPs) for wound debridement and remodeling.
نظرة عامة
هذه الصفحة جزء من مكتبة المركّبات المُصنَّفة بالأدلة في Hormonaly. جميع الادعاءات السريرية مرتبطة بمصادر علمية مُحكَّمة عبر خط أنابيب التحقق المزدوج للاستشهادات.
فئة المركّب
Copper-binding tripeptide / wound-healing peptide
آلية العمل
GHK-Cu (glycyl-l-histidyl-l-lysine complexed with copper) activates over 4,000 genes involved in tissue remodeling. Stimulates collagen, elastin, and glycosaminoglycan synthesis. Activates stem cells and TGF-β1 pathways. Anti-inflammatory via down-regulation of NF-κB. Promotes angiogenesis through VEGF and FGF-2. Copper chelation activity modulates metalloproteinase activity (MMPs) for wound debridement and remodeling.
الوضع التنظيمي
Not FDA approved as a drug. GHK-Cu is widely used as a cosmetic ingredient (no drug claim); wound-care products may carry FDA 510(k) clearance in some formulations.
مستوى الأدلة
Moderate — strong in vitro/preclinical data and clinical topical studies for wound healing and skin aging; limited RCT data for systemic use