Ashwagandha (KSM-66) — Adaptogen / Ayurvedic botanical
Ashwagandha's primary bioactive compounds are withanolides (especially withaferin A and withanolide D), alkaloids, and saponins. Mechanisms: (1) HPA axis modulation — reduces cortisol output via adrenal modulation; (2) GABA-A receptor modulation (triethylene glycol fraction) — anxiolytic; (3) testosterone/LH elevation in stressed/hypogonadal men via HPG axis normalization; (4) anti-inflammatory via NF-κB and COX-2 suppression; (5) thyroid stimulation (mild T4 elevation). KSM-66 is a full-spectrum root extract standardized to ≥5% withanolides with 22 clinical trials supporting it.
نظرة عامة
هذه الصفحة جزء من مكتبة المركّبات المُصنَّفة بالأدلة في Hormonaly. جميع الادعاءات السريرية مرتبطة بمصادر علمية مُحكَّمة عبر خط أنابيب التحقق المزدوج للاستشهادات.
فئة المركّب
Adaptogen / Ayurvedic botanical
آلية العمل
Ashwagandha's primary bioactive compounds are withanolides (especially withaferin A and withanolide D), alkaloids, and saponins. Mechanisms: (1) HPA axis modulation — reduces cortisol output via adrenal modulation; (2) GABA-A receptor modulation (triethylene glycol fraction) — anxiolytic; (3) testosterone/LH elevation in stressed/hypogonadal men via HPG axis normalization; (4) anti-inflammatory via NF-κB and COX-2 suppression; (5) thyroid stimulation (mild T4 elevation). KSM-66 is a full-spectrum root extract standardized to ≥5% withanolides with 22 clinical trials supporting it.
الوضع التنظيمي
OTC dietary supplement. GRAS status. Not FDA-approved for any indication.
مستوى الأدلة
Moderate — 22+ clinical trials for KSM-66 specifically. Multiple RCTs demonstrate stress reduction, cortisol lowering, and testosterone improvement. USPSTF has not reviewed. No formal guideline recommendations.